Endothelial Cell Mineralocorticoid Receptors
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptors modulate vascular endothelial function in human obesity.
Obesity increases linearly with age and is associated with impaired vascular endothelial function and increased risk of cardiovascular disease. MRs (mineralocorticoid receptors) contribute to impaired vascular endothelial function in cardiovascular disease; however, their role in uncomplicated human obesity is unknown. Because plasma aldosterone levels are elevated in obesity and adipocytes may...
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C linically, mineralocorticoid receptor (MR) antagonists are widely prescribed for the treatment of hyper-tension and heart failure because of their diuretic action in aldosterone-sensitive distal nephron. Clinical trials of MR antagonism in patients with various degrees of heart failure severity have also demonstrated a pronounced reduction of cardiovascular mortality in MR antagonist–treated ...
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Reconsolidation memory is defined as a process in which the retrieval of a previously consolidated memory returns to a labile state which is then subject to stabilization. Previous studies have shown that mineralocorticoid receptors (MRs) modulate distinct phases of learning and memory, which display a high concentration and distinct distribution in the hippocampus. Moreover, we found no studie...
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The hypertensive effect of mineralocorticoid excess or hyperaldosteronism has traditionally been attributed to upregulation of the epithelial Na channel ENaC in the kidney, with subsequent renal salt retention, increased plasma volume, augmented cardiac filling, and thus enhanced cardiac output.1 The effects of extracellular volume expansion and cardiac output on blood pressure at any given per...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2014
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.114.01997